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  • Hypotony Failure Criteria in Glaucoma Surgical Studies and Their Influence on Surgery Success

    PURPOSE: Review hypotony failure criteria used in glaucoma surgical outcome studies and evaluate their impact on success rates. DESIGN: Systematic...

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    Hypotony Failure Criteria in Glaucoma Surgical Studies and Their Influence on Surgery Success

    Hypotony Failure Criteria in Glaucoma Surgical Studies and Their Influence on Surgery Success

    PURPOSE: Review hypotony failure criteria used in glaucoma surgical outcome studies and evaluate...

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  • A foundation model for generalizable disease detection from retinal images

    Medical artificial intelligence (Al) offers great potential for recognizing signs of health conditions in retinal images and expediting the...

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    A foundation model for generalizable disease detection from retinal images

    A foundation model for generalizable disease detection from retinal images

    Medical artificial intelligence (Al) offers great potential for recognizing signs of health...

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  • Cost-effectiveness of primary surgical versus primary medical management in the treatment of patients presenting with advanced glaucoma

    Synopsis: Advanced glaucoma is associated with sight loss. This within-trial economic evaluation compares medical and surgical management...

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    Cost-effectiveness of primary surgical versus primary medical management in the treatment of patients presenting with advanced glaucoma

    Cost-effectiveness of primary surgical versus primary medical management in the treatment of patients presenting with advanced glaucoma

    Synopsis: Advanced glaucoma is associated with sight loss. This within-trial economic evaluation...

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  • Beware of acute corneal oedema after SLT in selected patients

    The Science behind the Tip The increase in the practice of selective laser trabeculoplasty (SLT) has brought attention to rare side effects such as...

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    Beware of acute corneal oedema after SLT in selected patients

    Beware of acute corneal oedema after SLT in selected patients

    The Science behind the Tip The increase in the practice of selective laser trabeculoplasty (SLT)...

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  • The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with many individuals living with more than one illness....

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    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...

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  • Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to misinterpretation of disease progression. Studies have...

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    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...

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  • Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG is to further the promotion of knowledge about the...

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    Angle Closure SIG

    Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...

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  • Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee (4), Sung Ryul Shim (5), Ahnul Ha (6) 1 Department...

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    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...

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  • Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather Eliassen (3,4,5,6), Lisa Frueh (3), Clary B Clish (7),...

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    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...

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  • Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês Silva (1), João Barbosa-Breda (1,2,3), Joana Araújo...

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    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...

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  • Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which can occur with drugs such as topiramate. The...

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    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...

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  • Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma filtration surgery (1). Cataract surgery causes anterior...

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    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma...

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Protective effect of lipoic acid against oxidative stress is mediated by Keap1/Nrf2-dependent heme oxygenase-1 induction in the RGC-5 cell line

Experimental Paper of the Month

Protective effect of lipoic acid against oxidative stress is mediated by Keap1/Nrf2-dependent heme oxygenase-1 induction in the RGC-5 cell line

Author(s): Koriyama Y, Nakayama Y, Matsugo S, Kato S. Department of Molecular Neurobiology, Graduate School of Medicine. Electronic address:...

February 28, 2013

Balance control in glaucoma

Clinical paper of the month

Balance control in glaucoma

Author(s): Kotecha A, Richardson G, Chopra R, Fahy RT, Garway-Heath DF, Rubin GS Department of Visual Neuroscience, University College London (UCL)...

January 31, 2013

A new safety concern for glaucoma treatment demonstrated by mass spectrometry imaging of benzalkonium chloride distribution in the eye, an experimental study in rabbits

Experimental Paper of the Month

A new safety concern for glaucoma treatment demonstrated by mass spectrometry imaging of benzalkonium chloride distribution in the eye, an experimental study in rabbits

Author(s): Brignole-Baudouin F, Desbenoit N, Hamm G, Liang H, Both JP, Brunelle A, Fournier I, Guerineau V, Legouffe R, Stauber J, Touboul D,...

January 31, 2013

Intravitreal steroids should be used with caution in patients with glaucoma

Tip of the month

Intravitreal steroids should be used with caution in patients with glaucoma

The Science behind the Tip In recent years it has become common practice to inject steroids into the vitreous to reduce macular oedema or ocular...

December 31, 2012

Factors that influence standard automated perimetry test results in glaucoma: test reliability, technician experience, time of day, and season

Clinical paper of the month

Factors that influence standard automated perimetry test results in glaucoma: test reliability, technician experience, time of day, and season

Author(s): Junoy Montolio FG, Wesselink C, Gordijn M, Jansonius NM Department of Ophthalmology, University Medical Center Groningen, University of...

December 31, 2012

Dorsomedial/Perifornical hypothalamic stimulation increases intraocular pressure, intracranial pressure, and the translaminar pressure gradient

Experimental Paper of the Month

Dorsomedial/Perifornical hypothalamic stimulation increases intraocular pressure, intracranial pressure, and the translaminar pressure gradient

Author(s): Samuels BC, Hammes NM, Johnson PL, Shekhar A, McKinnon SJ, Allingham RR Eugene and Marilyn Glick Eye Institute, the. PURPOSE:...

December 31, 2012

Long-term application of benzalkonium chloride increases the risk of filtration surgery failure

Tip of the month

Long-term application of benzalkonium chloride increases the risk of filtration surgery failure

The Science behind the Tip Glaucoma medication solutions usually contain the preservative benzalkonium chloride (BAK) in concentrations varying...

November 30, 2012

Retinal Vessel Caliber Is Associated with the 10-year Incidence of Glaucoma: The Blue Mountains Eye Study

Clinical paper of the month

Retinal Vessel Caliber Is Associated with the 10-year Incidence of Glaucoma: The Blue Mountains Eye Study

Author(s): Kawasaki R, Wang JJ, Rochtchina E, Lee AJ, Wong TY, Mitchell P. Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital,...

November 30, 2012

Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma

Experimental Paper of the Month

Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma

Author(s): Vithana EN, Khor CC, Qiao C, Nongpiur ME, George R, Chen LJ, Do T, Abu-Amero K, Huang CK, Low S, Tajudin LS, Perera SA, Cheng CY, Xu L,...

November 30, 2012

In patients with pseudoexfoliation glaucoma, phacoemulsification with IOL implantation can result in a late, sustained reduction in intraocular pressure

Tip of the month

In patients with pseudoexfoliation glaucoma, phacoemulsification with IOL implantation can result in a late, sustained reduction in intraocular pressure

The Science behind the Tip Raised intraocular pressure (IOP) in an eye with pseudoexfoliation syndrome results from pigment and exfoliation...

October 31, 2012

Longitudinal effect of topical antiglaucoma medications on central corneal thickness

Clinical paper of the month

Longitudinal effect of topical antiglaucoma medications on central corneal thickness

Author(s): Viswanathan D, Goldberg I, Graham SL Australian School of Advanced Medicine, Macquarie University, Sydney, Australia. BACKGROUND: To...

October 31, 2012

Intraocular pressure magnitude and variability as predictors of rates of structural change in non-human primate experimental glaucoma

Experimental Paper of the Month

Intraocular pressure magnitude and variability as predictors of rates of structural change in non-human primate experimental glaucoma

Author(s): Gardiner SK, Fortune B, Wang L, Downs JC, Burgoyne CF Devers Eye Institute, Legacy Health, 1225 NE 2nd Ave., Portland, OR 97232, USA....

October 31, 2012

Topical carbonic anhydrase inhibitors can cause damage in corneas with severe endothelial dysfunction

Tip of the month

Topical carbonic anhydrase inhibitors can cause damage in corneas with severe endothelial dysfunction

The Science behind the Tip The enzyme carbonic anhydrase is present in the corneal endothelium where it is involved in fluid transport (1). It thus...

September 30, 2012

Practical landmarks for visual field disability in glaucoma

Clinical paper of the month

Practical landmarks for visual field disability in glaucoma

Author(s): Saunders LJ, Russell RA, Crabb DP. City University London, London, UK. BACKGROUND/AIMS: To assess whether mean deviation (MD) from...

September 30, 2012

siRNA Silencing of Gene Expression in Trabecular Meshwork: RhoA siRNA Reduces IOP in Mice

Experimental Paper of the Month

siRNA Silencing of Gene Expression in Trabecular Meshwork: RhoA siRNA Reduces IOP in Mice

Author(s): Liu Q, Wu K, Qiu X, Yang Y, Lin X, Yu M Few reports described efficient transfection in the trabecular meshwork (TM) in vivo. In the...

September 30, 2012

The Relationship Between Statin Use and Open-Angle Glaucoma

Clinical paper of the month

The Relationship Between Statin Use and Open-Angle Glaucoma

Author(s): Stein JD, Newman-Casey PA, Talwar N, Nan B, Richards JE, Musch DC. Department of Ophthalmology and Visual Sciences, University of...

July 31, 2012

Structural and functional abnormalities of retinal ganglion cells measured in vivo at the onset of optic nerve head surface change in experimental glaucoma

Experimental Paper of the Month

Structural and functional abnormalities of retinal ganglion cells measured in vivo at the onset of optic nerve head surface change in experimental glaucoma

Author(s): Fortune B, Burgoyne CF, Cull GA, Reynaud J, Wang L. Devers Eye Institute, Discoveries in Sight Research Laboratories, Legacy Research...

July 31, 2012

In patients with progressive normal tension glaucoma, the use of topical brimonidine may help to preserve visual function

Tip of the month

In patients with progressive normal tension glaucoma, the use of topical brimonidine may help to preserve visual function

The Science behind the Tip A recent study has shown that visual function is more likely to be preserved with brimonidine 2% than with timolol 0.5%...

June 30, 2012

Do patients with glaucoma have difficulty recognising faces?

Clinical paper of the month

Do patients with glaucoma have difficulty recognising faces?

Author(s): Glen FC, Crabb DP, Smith ND, Burton R, Garway-Heath DF. Department of Optometry and Visual Science, City University London, Northampton...

June 30, 2012

IOP induces upregulation of GFAP and MHC-II and microglia reactivity in mice retina contralateral to experimental glaucoma

Experimental Paper of the Month

IOP induces upregulation of GFAP and MHC-II and microglia reactivity in mice retina contralateral to experimental glaucoma

Author(s): Gallego BI, Salazar JJ, de Hoz R, Rojas B, Ramírez AI, Salinas-Navarro M, Ortín-Martínez A, Valiente-Soriano FJ, Avilés-Trigueros M,...

June 30, 2012

A dry eye can hamper visual field test interpretation

Tip of the month

A dry eye can hamper visual field test interpretation

The Science behind the Tip During visual field (VF) testing the cornea of patients with severe dry eye condition can get dry to such an extent as...

May 31, 2012

Prevalence of cognitive impairment, depression, and anxiety symptoms among older adults with glaucoma

Clinical paper of the month

Prevalence of cognitive impairment, depression, and anxiety symptoms among older adults with glaucoma

Author(s): Yochim BP, Mueller AE, Kane KD, Kahook MY. Department of Psychology, University of Colorado at Colorado Springs, Colorado Springs...

May 31, 2012

JNK2 and JNK3 are major regulators of axonal injury-induced retinal ganglion cell death

Experimental Paper of the Month

JNK2 and JNK3 are major regulators of axonal injury-induced retinal ganglion cell death

Author(s): Fernandes KA, Harder JM, Fornarola LB, Freeman RS, Clark AF, Pang IH, John SW, Libby RT. Flaum Eye Institute, University of Rochester...

May 31, 2012

Laser peripheral iridotomy can reduce the intraocular pressure in pigment dispersion syndrome, but may not prevent glaucoma

Tip of the month

Laser peripheral iridotomy can reduce the intraocular pressure in pigment dispersion syndrome, but may not prevent glaucoma

The Science behind the Tip Nd-YAG laser peripheral iridotomy (PI) eliminates the reverse pressure gradient and intermittent posterior bowing of the...

April 30, 2012

The effect of thin, thick, and normal corneas on Goldmann intraocular pressure measurements and correction formulae in individual eyes

Clinical paper of the month

The effect of thin, thick, and normal corneas on Goldmann intraocular pressure measurements and correction formulae in individual eyes

Author(s): Park SJ, Ang GS, Nicholas S, Wells AP. Eye Department, Wellington Hospital, Capital and Coast District Health Board, Wellington, New...

April 30, 2012