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Identification of Optic Nerve–Related Biomarkers in Primary Open-Angle Glaucoma Based on Comprehensive Bioinformatics and Mendelian Randomization
Purpose: Glaucoma is the primary cause of permanent vision loss worldwide. However, the...
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Quality of Life and Primary Open-Angle Glaucoma in the Ocular Hypertension Treatment Study
Importance: If preperimetric glaucoma reduces patient-reported vision-related quality of life...
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Fatal beauty: which cosmetics are your glaucoma patients using?
Colorism refers to the difference in social treatment between light-skinned and dark-skinned...
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The relationship between multiple deprivation and severity of glaucoma at diagnosis
BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...
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Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank
Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...
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Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients
Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...
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Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis
Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...
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Angle Closure SIG
SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...
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Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists
Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...
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Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure
The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...
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Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery
The accelerated development of cataract is frequently seen in the years following glaucoma...
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Lifestyle and risk of developing open-angle glaucoma: the Rotterdam study
Author(s): Ramdas WD, Wolfs RC, Hofman A, de Jong PT, Vingerling JR, Jansonius NM. Department of Ophthalmology, Erasmus Medical Center Rotterdam,...
July 31, 2011
Ex vivo optical coherence tomography imaging of collector channels with a scanning endoscopic probe
Author(s): Ren J, Gille HK, Wu J, Yang C. Departments of Electrical Engineering and. PURPOSE: To achieve high-fidelity optical coherence tomography...
July 31, 2011
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Rim/disc ratio is a more sensitive parameter than cup/disc ratio
The Science behind the Tip Routine fundus observation of the optic disc is helpful in the diagnosis of early glaucoma and it is often key in the...
June 30, 2011
Risk factors for visual field progression in treated glaucoma
Author(s): De Moraes CG, Juthani VJ, Liebmann JM, Teng CC, Tello C, Susanna R Jr, Ritch R. OBJECTIVE: To determine intraocular pressure...
June 30, 2011
Distortion of axonal cytoskeleton: an early sign of glaucomatous damage
Author(s): Huang X, Kong W, Zhou Y, Gregori G. PURPOSE: Glaucoma damages the retinal nerve fiber layer (RNFL). The purpose of this study was to...
June 30, 2011
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In patients with juvenile-onset chronic open-angle glaucoma, trabeculectomy with mitomycin C is usually required to prevent progressive visual loss
The Science behind the Tip Juvenile-onset chronic open-angle glaucoma is inherited in an autosomal dominant fashion with high penetrance....
May 31, 2011
The Relationship Between Components of Metabolic Syndrome and Open-Angle Glaucoma
Author(s): Newman-Casey PA, Talwar N, Nan B, Musch DC, Stein JD. Department of Ophthalmology and Visual Sciences, University of Michigan Medical...
May 31, 2011
Elastic modulus determination of normal and glaucomatous human trabecular meshwork
Author(s): Last JA, Pan T, Ding Y, Reilly CM, Keller K, Acott TS, Fautsch MP, Murphy CJ, Russell P. Department of Chemical and Biological...
May 31, 2011
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The advantage of adding a 3rd or 4th drug may be negligible
The Science behind the Tip With the arrival of combination products, our threshold for prescribing multiple glaucoma medications has significantly...
April 30, 2011
A Randomized Trial of Brimonidine Versus Timolol in Preserving Visual Function: Results From the Low-pressure Glaucoma Treatment Study
Author(s): Krupin T, Liebmann JM, Greenfield DS, Ritch R, Gardiner S. Department of Ophthalmology, Feinberg School of Medicine, Northwestern...
April 30, 2011
Early Gene Expression Changes in the Retinal Ganglion Cell Layer of a Rat Glaucoma Model
Author(s): Guo Y, Johnson EC, Cepurna WO, Dyck J, Doser T, Morrison JC. Ophthalmology, Oregon Health & Sciences University, Portland, United...
April 30, 2011
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The most effective treatment of glaucoma associated with epithelial downgrowth is to insert a drainage implant
The Science behind the Tip Epithelial downgrowth into the anterior chamber is an extremely rare cause of glaucoma after anterior segment incisional...
March 31, 2011
Investigation of the Association between Helicobacter pylori Infection and Normal Tension Glaucoma
Author(s): Kim JM, Kim SH, Park KH, Han SY, Shim HS. Department of Ophthalmology, Sungkyunkwan University School of Medicine, Kangbuk Samsung...
March 31, 2011
Imaging the aqueous humor outflow pathway in human eyes by three-dimensional micro-computed tomography (3D micro-CT)
Author(s): Hann CR, Bentley MD, Vercnocke A, Ritman EL, Fautsch MP Department of Ophthalmology, Mayo Clinic, 200 First Street SW, Rochester, MN...
March 31, 2011
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Chronic miotics can be helpful in case of plateau iris configuration
The Science behind the Tip Long term miotics are seldom prescribed nowadays. Still the drugs remain useful in case of plateau iris configuration, a...
February 28, 2011
Laminar and prelaminar tissue displacement during intraocular pressure elevation in glaucoma patients and healthy controls
Author(s): Agoumi Y, Sharpe GP, Hutchison DM, Nicolela MT, Artes PH, Chauhan BC. Department of Ophthalmology and Visual Sciences, Dalhousie...
February 28, 2011
Evidence for a role of angiopoietin-like 7 (ANGPTL7) in extracellular matrix formation of the human trabecular meshwork: implications for glaucoma
Author(s): Comes N, Buie LK, Borrás T. Department of Ophthalmology, University of North Carolina School of Medicine, Chapel Hill, NC, USA. The...
February 28, 2011
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To reduce the risk of late bleb-related infection, avoid multiple-dose eye drops in patients who have previously undergone trabeculectomy with mitomycin C
The Science behind the Tip Bleb-related infection is a devastating and potentially blinding late consequence of trabeculectomy, particularly if...
January 31, 2011
Intravitreal injections of neurotrophic factors secreting mesenchymal stem cells are neuroprotective in rat eyes following optic nerve transection
Author(s): Levkovitch-Verbin H, Sadan O, Vander S, Rosner M, Barhum Y, Melamed E, Offen D, Melamed S. Goldschleger Eye Institute, Sheba Medical...
January 31, 2011
Reversal of retinal ganglion cell dysfunction after surgical reduction of intraocular pressure
Author(s): Sehi M, Grewal DS, Goodkin ML, Greenfield DS. Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller...
January 31, 2011
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Small field depressions can be more worrying than large ones
The Science behind the Tip Much of the decision making in modern glaucoma practice is based on automated visual field test results. Careful...
December 31, 2010
Predicting visual function from the measurements of retinal nerve fiber layer structure
Author(s): Zhu H, Crabb DP, Schlottmann PG, Lemij HG, Reus NJ, Healey PR, Mitchell P, Ho T, Garway-Heath DF Department of Optometry and Visual...
December 31, 2010
Canadian Glaucoma Study: 3. Impact of risk factors and intraocular pressure reduction on the rates of visual field change
Author(s): Chauhan BC, Mikelberg FS, Artes PH, Balazsi AG, LeBlanc RP, Lesk MR, Nicolela MT, Trope GE; Canadian Glaucoma Study Group Collaborators...
November 30, 2010
Qualitative and quantitative morphologic changes in the vasculature and extracellular matrix of the prelaminar optic nerve head in eyes with POAG
Author(s): Tektas OY, Lütjen-Drecoll E, Scholz M Institute of Anatomy II, University of Erlangen-Nuremberg, Erlangen, Germany....
November 30, 2010
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The cataract surgeon should be informed that the patient has pseudo-exfoliation syndrome
The Science behind the Tip Although the diagnosis of pseudo-exfoliation syndrome (PEX) with a fully dilated pupil in an elderly patient should pose...
October 31, 2010