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  • Hypotony Failure Criteria in Glaucoma Surgical Studies and Their Influence on Surgery Success

    PURPOSE: Review hypotony failure criteria used in glaucoma surgical outcome studies and evaluate their impact on success rates. DESIGN: Systematic...

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    Hypotony Failure Criteria in Glaucoma Surgical Studies and Their Influence on Surgery Success

    Hypotony Failure Criteria in Glaucoma Surgical Studies and Their Influence on Surgery Success

    PURPOSE: Review hypotony failure criteria used in glaucoma surgical outcome studies and evaluate...

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  • A foundation model for generalizable disease detection from retinal images

    Medical artificial intelligence (Al) offers great potential for recognizing signs of health conditions in retinal images and expediting the...

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    A foundation model for generalizable disease detection from retinal images

    A foundation model for generalizable disease detection from retinal images

    Medical artificial intelligence (Al) offers great potential for recognizing signs of health...

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  • Cost-effectiveness of primary surgical versus primary medical management in the treatment of patients presenting with advanced glaucoma

    Synopsis: Advanced glaucoma is associated with sight loss. This within-trial economic evaluation compares medical and surgical management...

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    Cost-effectiveness of primary surgical versus primary medical management in the treatment of patients presenting with advanced glaucoma

    Cost-effectiveness of primary surgical versus primary medical management in the treatment of patients presenting with advanced glaucoma

    Synopsis: Advanced glaucoma is associated with sight loss. This within-trial economic evaluation...

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  • Beware of acute corneal oedema after SLT in selected patients

    The Science behind the Tip The increase in the practice of selective laser trabeculoplasty (SLT) has brought attention to rare side effects such as...

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    Beware of acute corneal oedema after SLT in selected patients

    Beware of acute corneal oedema after SLT in selected patients

    The Science behind the Tip The increase in the practice of selective laser trabeculoplasty (SLT)...

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  • The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with many individuals living with more than one illness....

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    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...

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  • Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to misinterpretation of disease progression. Studies have...

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    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...

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  • Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG is to further the promotion of knowledge about the...

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    Angle Closure SIG

    Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...

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  • Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee (4), Sung Ryul Shim (5), Ahnul Ha (6) 1 Department...

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    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...

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  • Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather Eliassen (3,4,5,6), Lisa Frueh (3), Clary B Clish (7),...

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    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...

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  • Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês Silva (1), João Barbosa-Breda (1,2,3), Joana Araújo...

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    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...

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  • Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which can occur with drugs such as topiramate. The...

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    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...

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  • Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma filtration surgery (1). Cataract surgery causes anterior...

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    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma...

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Cerebrospinal fluid exchange in the optic nerve in normal-tension glaucoma

Experimental Paper of the Month

Cerebrospinal fluid exchange in the optic nerve in normal-tension glaucoma

Author(s): Killer HE, Miller NR, Flammer J, Meyer P, Weinreb RN, Remonda L, Jaggi GP. Kantonsspital Aarau, CH-5001 Aarau, Switzerland;...

April 30, 2012

Gonioscopy should be performed using the minimal possible levels of illumination in order to reliably detect appositional angle closure

Tip of the month

Gonioscopy should be performed using the minimal possible levels of illumination in order to reliably detect appositional angle closure

The Science behind the Tip Anterior chamber angle width varies dramatically with illumination (figure and video in ref. 1) (1,2). Visible...

March 31, 2012

Cataract surgery after trabeculectomy: the effect on trabeculectomy function

Clinical paper of the month

Cataract surgery after trabeculectomy: the effect on trabeculectomy function

Author(s): Husain R, Liang S, Foster PJ, Gazzard G, Bunce C, Chew PT, Oen FT, Khaw PT, Seah SK, Aung T FRCS(Edin), Singapore National Eye Center,...

March 31, 2012

Multipotent Stem Cells from Trabecular Meshwork Become Phagocytic TM cells

Experimental Paper of the Month

Multipotent Stem Cells from Trabecular Meshwork Become Phagocytic TM cells

Author(s): Du Y, Roh DS, Mann MM, Funderburgh ML, Funderburgh JL, Schuman JS. UPMC Eye Center, Ophthalmology and Visual Science Research Center,...

March 31, 2012

Laser peripheral iridotomy does not usually result in long-term intraocular pressure control in patients with chronic angle-closure glaucoma

Tip of the month

Laser peripheral iridotomy does not usually result in long-term intraocular pressure control in patients with chronic angle-closure glaucoma

The Science behind the Tip The initial treatment of chronic angle-closure glaucoma is to undertake a laser peripheral iridotomy (PI) to prevent...

February 29, 2012

Outcomes of different management options for malignant glaucoma: a retrospective study

Clinical paper of the month

Outcomes of different management options for malignant glaucoma: a retrospective study

Author(s): Debrouwere V, Stalmans P, Van Calster J, Spileers W, Zeyen T, Stalmans I. Department of Ophthalmology, Kapucijnenvoer 33, 3000, Leuven,...

February 29, 2012

A New Approach to Assess Intracranial White Matter Abnormalities in Glaucoma Patients Changes of Fractional Anisotropy Detected by 3T Diffusion Tensor Imaging

Experimental Paper of the Month

A New Approach to Assess Intracranial White Matter Abnormalities in Glaucoma Patients Changes of Fractional Anisotropy Detected by 3T Diffusion Tensor Imaging

Author(s): Engelhorn T, Michelson G, Waerntges S, Hempel S, El-Rafei A, Struffert T, Doerfler A. Department of Neuroradiology, University of...

February 29, 2012

Trial lens artifacts can be easily distinguished from glaucomatous field defects

Tip of the month

Trial lens artifacts can be easily distinguished from glaucomatous field defects

The Science behind the Tip False depressions due to a misaligned trial lens or a lens holder which was placed too far from the patient's eye are...

January 31, 2012

Optic nerve sheath diameter in normal-tension glaucoma patients

Clinical paper of the month

Optic nerve sheath diameter in normal-tension glaucoma patients

Author(s): Jaggi GP, Miller NR, Flammer J, Weinreb RN, Remonda L, Killer HE. Kantonsspital Aarau, Buchserstrasse, CH-5001 Aarau, Switzerland;...

January 31, 2012

Vision deficits precede structural losses in a mouse model of mitochondrial dysfunction and progressive retinal degeneration

Experimental Paper of the Month

Vision deficits precede structural losses in a mouse model of mitochondrial dysfunction and progressive retinal degeneration

Author(s): Laliberté AM, Macpherson TC, Micks T, Yan A, Hill KA Department of Biology, The University of Western Ontario, London, Ontario N6A 5B7,...

January 31, 2012

In neovascular glaucoma, the immediate injection of intravitreal bevacizumab (Avastin®) usually results in rapid regression of iris new vessels and pain relief

Tip of the month

In neovascular glaucoma, the immediate injection of intravitreal bevacizumab (Avastin®) usually results in rapid regression of iris new vessels and pain relief

The Science behind the Tip Neovascular glaucoma is a devastating consequence of diseases like proliferative diabetic retinopathy and ischaemic...

December 31, 2011

The Association between Glaucomatous and Other Causes of Optic Neuropathy and Sleep Apnea.

Clinical paper of the month

The Association between Glaucomatous and Other Causes of Optic Neuropathy and Sleep Apnea.

Author(s): Stein JD, Kim DS, Mundy KM, Talwar N, Nan B, Chervin RD, Musch DC. Department of Ophthalmology and Visual Sciences, University of...

December 31, 2011

IOP-Induced Lamina Cribrosa Deformation and Scleral Canal Expansion: Independent or Related?

Experimental Paper of the Month

IOP-Induced Lamina Cribrosa Deformation and Scleral Canal Expansion: Independent or Related?

Author(s): Sigal IA, Yang H, Roberts MD, Grimm JL, Burgoyne CF, Demirel S, Downs JC. Ocular Biomechanics Laboratory. PURPOSE: To study the...

December 31, 2011

Genetic architecture of open angle glaucoma and related determinants

Experimental Paper of the Month

Genetic architecture of open angle glaucoma and related determinants

Author(s): Ramdas WD, Amin N, van Koolwijk LM, Janssens AC, Demirkan A, de Jong PT, Aulchenko YS, Wolfs RC, Hofman A, Rivadeneira F, Uitterlinden...

December 31, 2011

Washout periods vary significantly between glaucoma medications

Tip of the month

Washout periods vary significantly between glaucoma medications

The Science behind the Tip Knowledge of the washout periods for topical medications is crucial for the evaluation of the effects of their...

November 30, 2011

Shrinkage of the scleral canal during cupping reversal in children.

Clinical paper of the month

Shrinkage of the scleral canal during cupping reversal in children.

Author(s): Mochizuki H, Lesley AG, Brandt JD. Department of Ophthalmology and Vision Science, University of California, Davis; Department of...

November 30, 2011

Identification of a Novel Locus for Autosomal Dominant Primary Open Angle Glaucoma on 4q35.1-q35.2.

Experimental Paper of the Month

Identification of a Novel Locus for Autosomal Dominant Primary Open Angle Glaucoma on 4q35.1-q35.2.

Author(s): Porter LF, Urquhart JE, O'Donoghue E, Spencer AF, Wade EM, Manson FD, Black GC. School of Biomedicine, The University of Manchester,...

November 30, 2011

To prevent early hypotony with a non-valved aqeous shunt, always occlude the tube with a suture

Tip of the month

To prevent early hypotony with a non-valved aqeous shunt, always occlude the tube with a suture

The Science behind the Tip The safe use of non-valved aqueous shunt implants, such as the Baerveldt (Advanced Medical Optics, Inc., Irvine,...

October 31, 2011

Intraocular Pressure Control and Long-term Visual Field Loss in the Collaborative Initial Glaucoma Treatment Study

Clinical paper of the month

Intraocular Pressure Control and Long-term Visual Field Loss in the Collaborative Initial Glaucoma Treatment Study

Author(s): Musch DC, Gillespie BW, Niziol LM, Lichter PR, Varma R; CIGTS Study Group. Department of Ophthalmology and Visual Sciences, University...

October 31, 2011

24-Hour IOP Telemetry in the Non-human Primate: Implant System Performance and Initial Characterization of IOP At Multiple Timescales

Experimental Paper of the Month

24-Hour IOP Telemetry in the Non-human Primate: Implant System Performance and Initial Characterization of IOP At Multiple Timescales

Author(s): Downs JC, Burgoyne CF, Seigfreid WP, Reynaud JF, Strouthidis NG, Sallee V. Ocular Biomechanics Laboratory, Devers Eye Institute,...

October 31, 2011

Prostaglandin analogues should be avoided in patients with a history of herpes keratitis

Tip of the month

Prostaglandin analogues should be avoided in patients with a history of herpes keratitis

The Science behind the Tip Topical prostaglandins are commonly used as first-line and second-line therapy in patients with ocular hypertension and...

September 30, 2011

Vision loss and recovery after trabeculectomy: risk and associated risk factors

Clinical paper of the month

Vision loss and recovery after trabeculectomy: risk and associated risk factors

Author(s): Francis BA, Hong B, Winarko J, Kawji S, Dustin L, Chopra V. Doheny Eye Institute, Department of Ophthalmology, Keck School of Medicine,...

September 30, 2011

Activated retinal glia mediated axon regeneration in experimental glaucoma

Experimental Paper of the Month

Activated retinal glia mediated axon regeneration in experimental glaucoma

Author(s): Lorber B, Guidi A, Fawcett JW, Martin KR. Centre for Brain Repair, University of Cambridge, Cambridge, UK. Glaucoma, a leading cause of...

September 30, 2011

Trans-lamina cribrosa pressure difference correlated with neuroretinal rim area in glaucoma

Clinical paper of the month

Trans-lamina cribrosa pressure difference correlated with neuroretinal rim area in glaucoma

Author(s): Ren R, Wang N, Zhang X, Cui T, Jonas JB Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital,...

August 31, 2011

During Glaucoma, {alpha}2-Macroglobulin Accumulates in Aqueous Humor and Binds to Nerve Growth Factor, Neutralizing Neuroprotection

Experimental Paper of the Month

During Glaucoma, {alpha}2-Macroglobulin Accumulates in Aqueous Humor and Binds to Nerve Growth Factor, Neutralizing Neuroprotection

Author(s): Bai Y, Sivori D, Woo SB, Neet KE, Lerner SF, Saragovi HU Lady Davis Institute-Jewish General Hospital PURPOSE: Glaucoma is an optic...

August 31, 2011